Cold‐stored platelets have better preserved contractile function in comparison with room temperature‐stored platelets over 21 days

نویسندگان

چکیده

Although it is well established that transfusion of platelets in cases severe bleeding reduces mortality, the availability hampered by harsh restrictions on shelf life due to elevated risks microbial contamination and functional losses with room temperature-stored (RTP) kept at 22°C. In contrast, many recent studies have shown 4°C cold-stored (CSP) are able overcome these shortcomings leading Food Drug Administration licensure for 14-day stored CSP when conventional unavailable. This work expands evidence supporting superiority function assaying less explored platelet-mediated clot retraction RTP either autologous plasma (AP) or platelet additive solution (PAS) up 21 days. The results demonstrate better preservation contractile function, exhibiting days both AP PAS forming highly ordered fibrin scaffolds similar those fresh platelets. showed impaired Day 5 no after 10 days, whereas PAS-stored retained Collectively, findings support extended storage suggest can mitigate RTP.

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ژورنال

عنوان ژورنال: Transfusion

سال: 2021

ISSN: ['0041-1132', '1537-2995']

DOI: https://doi.org/10.1111/trf.16530